Case Report: Post-gastrectomy reactive hyperinsulinemic hypoglicaemia: glucose trends before and after canagliflozin treatment
نویسندگان
چکیده
The pathogenesis of post-gastrectomy reactive hyperinsulinaemic hypoglycaemia is not yet fully clarified. Recent studies suggest an up-regulation the intestinal glucose transporter SGLT-1 aimed to prevent carbohydrate malabsorption. overexpression could therefore represents one mechanisms underlying wide glycemic excursions found in patients after gastrectomy, but investigating use SGLT-1/SGLT-2 inhibitors with hyperinsulinemic are very scant literature. We report case a 37-year-old non diabetic man who frequently presented symptoms postprandial period. In 2012, he underwent Roux en-Y gastric bypass (RYGB) and two years, started experience typical hypoglycaemia. suggested healthy modifications dietary habits periodic follow-up visits dietitian. After three months, patient still hypoglycaemia; we provided him Flash Glucose Monitoring (FGM) assess trend levels interstitial fluid during day decided introduce canagliflozin 300 mg/day before main meal. Hypoglycaemic events previously referred by clearly recorded FGM completely disappeared taking canagliflozin. reduction time spent hypoglycaemia, improvement variability increase target range. It was also noted hyperglicemia consequent average values indicator. This first supporting role management Our preliminary results limited line those literature showed for hypoglycaemic through flash monitoring system. Further mandatory confirm this therapeutic opportunity.
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2023
ISSN: ['1664-2392']
DOI: https://doi.org/10.3389/fendo.2023.1193696